At close, the Sensex was down 388.40 points or 0.59 percent at 65,151.02, and the Nifty was down 99.70 points or 0.51 percent at 19,365.30. ITC, LTIMindtree, Divis Lab, Power Grid and Reliance Industries were among the top losers on the Nifty, while gainers included Adani Ports, Titan Company, Adani Enterprises, Bajaj Auto and SBI.